Paper Publications
1. A High-Throughput Phenotypic Screen of Cytotoxic T Lymphocyte Lytic Granule Exocytosis Reveals Candidate Immunosuppressants.
Zhao Z, Haynes MK, Ursu O, Edwards BS, Sklar LA, Zweifach A.
J Biomol Screen. 2014 Nov 7. pii: 1087057114557620. [Epub ahead of print]
PMID: 25381253 [PubMed - as supplied by publisher]
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2. Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis.
Florian AE, Lepensky CK, Kwon O, Haynes MK, Sklar LA, Zweifach A.
J Biomol Screen. 2013 Apr;18(4):420-9. doi: 10.1177/1087057112466697. Epub 2012 Nov 15.
PMID: 23160568 [PubMed - indexed for MEDLINE] Free PMC Article
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3. Calcium influx and signaling in cytotoxic T-lymphocyte lytic granule exocytosis.
Pores-Fernando AT, Zweifach A.
Immunol Rev. 2009 Sep;231(1):160-73. doi: 10.1111/j.1600-065X.2009.00809.x. Review.
PMID: 19754896 [PubMed - indexed for MEDLINE]
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4. No specific subcellular localization of protein kinase C is required for cytotoxic T cell granule exocytosis.
Pores-Fernando AT, Ranaghan MY, Zweifach A.
J Biol Chem. 2009 Sep 11;284(37):25107-15. doi: 10.1074/jbc.M109.011866. Epub 2009 Jul 10.
PMID: 19592494 [PubMed - indexed for MEDLINE] Free PMC Article
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5. Calcineurin-dependent lytic granule exocytosis in NK-92 natural killer cells.
Pores-Fernando AT, Gaur S, Doyon MY, Zweifach A.
Cell Immunol. 2009;254(2):105-9. doi: 10.1016/j.cellimm.2008.07.004. Epub 2008 Aug 30.
PMID: 18762287 [PubMed - indexed for MEDLINE] Free PMC Article
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6. ERK activation is only one role of PKC in TCR-independent cytotoxic T cell granule exocytosis.
Pores-Fernando AT, Gaur S, Grybko MJ, Zweifach A.
Biochem Biophys Res Commun. 2008 Jul 11;371(4):630-4. doi: 10.1016/j.bbrc.2008.04.028. Epub 2008 Apr 14.
PMID: 18413231 [PubMed - indexed for MEDLINE] Free PMC Article
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7. Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis.
Grybko MJ, Bartnik JP, Wurth GA, Pores-Fernando AT, Zweifach A.
J Biol Chem. 2007 Jun 22;282(25):18009-17. Epub 2007 May 2.
PMID: 17478429 [PubMed - indexed for MEDLINE] Free Article
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8. Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role.
Grybko MJ, Pores-Fernando AT, Wurth GA, Zweifach A.
J Leukoc Biol. 2007 Feb;81(2):509-19. Epub 2006 Oct 31.
PMID: 17077164 [PubMed - indexed for MEDLINE] Free Article
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9. Exocytic responses of single leukaemic human cytotoxic T lymphocytes stimulated by agents that bypass the T cell receptor.
Pores-Fernando AT, Bauer RA, Wurth GA, Zweifach A.
J Physiol. 2005 Sep 15;567(Pt 3):891-903. Epub 2005 Jul 14.
PMID: 16020463 [PubMed - indexed for MEDLINE] Free PMC Article
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10. Interactions of the allogeneic effector leukemic T cell line, TALL-104, with human malignant brain tumors.
Gomez GG, Read SB, Gerschenson LE, Santoli D, Zweifach A, Kruse CA.
Neuro Oncol. 2004 Apr;6(2):83-95.
PMID: 15134622 [PubMed - indexed for MEDLINE] Free PMC Article
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11. Cross-talk with Ca(2+) influx does not underlie the role of extracellular signal-regulated kinases in cytotoxic T lymphocyte lytic granule exocytosis.
Fierro AF, Wurth GA, Zweifach A.
J Biol Chem. 2004 Jun 11;279(24):25646-52. Epub 2004 Apr 1.
PMID: 15060074 [PubMed - indexed for MEDLINE] Free Article
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12. Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition.
Headley VV, Tanveer R, Greene SM, Zweifach A, Port JD.
Mol Cell Biochem. 2004 Mar;258(1-2):109-19.
PMID: 15030175 [PubMed - indexed for MEDLINE]
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13. The actin cytoskeleton and cytotoxic T lymphocytes: evidence for multiple roles that could affect granule exocytosis-dependent target cell killing.
Lyubchenko TA, Wurth GA, Zweifach A.
J Physiol. 2003 Mar 15;547(Pt 3):835-47. Epub 2003 Feb 7.
PMID: 12576500 [PubMed - indexed for MEDLINE] Free PMC Article
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14. Evidence that cytosolic calcium increases are not sufficient to stimulate phospholipid scrambling in human T-lymphocytes.
Wurth GA, Zweifach A.
Biochem J. 2002 Mar 15;362(Pt 3):701-8.
PMID: 11879198 [PubMed - indexed for MEDLINE] Free PMC Article
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Online Reports
1. Summary of HTS Screening Project for Inhibitors of Lytic Granule Exocytosis [Summary]
AID: 651682 NMMLSC: UNMCMD_CTL_LyticGranule_Summary
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720670
2. Inhibition of Calcium signaling with compounds from CherryPick01 [Primary Screening]
Assay data: 19 Active75 Tested
AID: 720670 NMMLSC: UNMCMD_CTL_Fura2_CP01
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720669
3. Inhibition of Calcineurin activity by compounds from CherryPick01 [Primary Screening]
Assay data: 1 Active22 Tested
AID: 720669 NMMLSC: UNMCMD_CTL_Calcineurin_CP01
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720667
4. Inhibition of MAPKK activation by compounds from CherryPick01 [Primary Screening]
Assay data: 7 Active27 Tested
AID: 720667 NMMLSC: UNMCMD_CTL_MAPKK_CP01
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720668
5. Inhibition of MAP Kinase activation by compounds from CherryPick01 [Primary Screening]
Assay data: 22 Tested
AID: 720668 NMMLSC: UNMCMD_CTL_MAPKERK_CP01
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720666
6. Inhibition of Protein Kinase C activation by compounds from CherryPick01 [Primary Screening]
Assay data: 27 Tested
AID: 720666 NMMLSC: UNMCMD_CTL_PKC_CP01
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720665
7. Inhibition of Calcium signaling with compounds from CherryPick01 tested with FuraRed [Primary Screening]
Assay data: 8 Tested
AID: 720665 NMMLSC: UNMCMD_CTL_FuraRed_CP01
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720663
8. Inhibition of Exocytosis of Lytic Granulocytes as measured by LAMP-1 externalization with compounds from CherryPick01 [Primary Screening]
Assay data: 47 Active75 Tested
AID: 720663 NMMLSC: UNMCMD_CTL_LAMP_CP01
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 720662
9. Inhibition of granule serine esterase secretion with compounds from CherryPick01 [Primary Screening]
Assay data: 40 Active75 Tested
AID: 720662 NMMLSC: UNMCMD_CTL_BTL_CP01
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 652101
10. Dose Response of Inhibitors of Lytic Granule Exocytosis with compounds from CherryPick01 [Confirmatory]
Assay data: 45 Active3 Activity ≤ 1 µM160 Tested
AID: 652101 NMMLSC: UNMCMD_CTL_LyticGranule_DR_CP01
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 651954
11. Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with compounds from Cherry Pick01 [Primary Screening]
Assay data: 161 Active1460 Tested
AID: 651954 NMMLSC: UNMCMD_CTL_LyticGranule_CP01
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 651702
12. Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [Primary Screening]
Assay data: 2404 Active364202 Tested
AID: 651702 NMMLSC: UNMCMD_CTL_LyticGranule_MLPCN
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Select item 651664
13. Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with Validation Set [Primary Screening]
Assay data: 5 Active1837 Tested
AID: 651664 NMMLSC: UNMCMD_CTL_LyticGranule_Validation
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project